--- title: "Urine Toxicology (MGH)" url: https://mghmclean.org/residents/handbk/part2a/tox.htm description: "Urine Toxicology (MGH) - a chapter of the MGH/McLean Residency Training Program in Psychiatry manual." published: 2026-08-10 updated: 2026-08-10 --- # Urine Toxicology (MGH) Published 2026-08-10 PART 3 / CH 17 | Drug Class or Drug | Duration of Positive Result | Comments | |---|---|---| | Amphetamines | 1-3 days post use | -false (+) possible: chlorpromazine, buproprion, propranalol, chloroquine, ephedrine, pseudoephedrine, phenylpropanolamine (Dexatrim), selegiline, tranylcypromine, tyramine | | Barbiturates | 2-20d: depends on drug | -short acting agents detectable ~24hrs -long acting up to 3 wks | | Benzodiazepines | 1-14 days | | | Cannabanoids | 2-7 days if use 4x/week, up to 10 days with daily use | (May be positive up to 1 month in case of chronic use) | | Opiates/ Metabolites(codeine, morphine)may detect high concentrations of meperidine, oxycodone, oxymorphone | 2-3 days after use | -may yield more true positives than serum tox-not specific to heroin or illicit opiods-naloxone, propoxyphene, nalbuphine, methadone fentanyl, propofol do not cross-react-false (+) with poppyseeds | | Cocaine Metabolite | Peak 4 hrs post exposure, (+) 2-4 days post use | (May be positive for 7-22 days after use in chronic high-dose abusers) | | Phencyclidine | 10-20 days post use | more true (+) vs serum tox, but false (+) may occur with dextromethorphan | ## Serum Toxicology (MGH) | | Drugs Included | Therapeutic Range | Toxic Range | |---|---|---|---| | Tox Panel 1 | ethanolisopropanolmethanol | not definednot definednot defined | >1000>400>200 | | Tox Panel 2 | acetominophensalicylatetheophylline | 10-25100-20010-20 | >120>300>25 | | Tox Panel 3 | butalbitalcarbamazepineibuprofenpentobarbitalphenobarbitalphenytoinsecobarbital | 5-104-1220-70not defined15-2010-20not defined | >20>15>100>15>60>25>10 | | Tox Panel 4 | alprazolamchlordiazepoxideclonazepamdemoxepamdiazepamdesalkyflurazepamflurazepamglutethimidelidocainelorazepammethaqualonenorchlordiazepoxidenordiazepamoxazepamquinidinetemazepamtrazodone4-OH-glutethimide | 19-551000-300010-70not defined100-100020-11010-1002000-60001500-500050-240not defined1000-3000100-800200-14001200-4000190-540800-1600not defined | not defined>5000>80not defined>5000>500>200>7000>6000not defined>10000>5000>5000>5000>5000not definednot defined>15000 | Tox Panel 5 amitriptyline chlorpheniramine chlorpromazine clomipramine clozapine cocaethylene cocaine cyclobenzaprine D-pseudoephedrine desipramine desmethylsertraline dextromethorphan diphenhydramine disopyramide doxepin doxylamine fluoxetine fluvoxamine imipramine maprotilene ## MCPP meperidine mesoridazine methadone metoprolol norclomipramine nordoxepin norfluoxetine normaprotilene normeperidine norpropoxyphene nortriptyline norverapamil oxycodone paroxetine pentazocine promazine propoxyphene propranolol pyrilamine sertraline thioridazine trifluoperazine trimipramine venlafaxine verapamil 120-250 5-20 50-500 150-450 150-500 not defined not defined 20-30 36-80 150-300 not defined not defined not defined 2000-5000 150-250 not defined 50-450 12-240 150-250 180-450 not defined 70-500 150-1000 50-800 20-340 not defined 150-250 50-450 not defined not defined 100-1500 50-150 not defined 10-40 20-190 50-200 100-500 100-400 50-100 not defined 40-160 250-1250 not defined 50-200 not defined 100-400 >500 not defined >1000 not defined not defined not defined not defined not defined >2000 >500 not defined not defined >200 >8000 >500 not defined not defined not defined >500 >800 not defined >1000 not defined >2000 not defined not defined >500 not defined >800 not defined >2000 >500 not defined not defined not defined >1000 >1000 >500 not defined not defined not defined >1000 not defined not defined not defined >400